A marginal rank-based inverse normal transformation approach to comparing multiple clinical trial endpoints
نویسندگان
چکیده
منابع مشابه
A Weighted Rank-Sum Procedure for Comparing Samples with Multiple Endpoints.
For comparing the distribution of two samples with multiple endpoints, O'Brien (1984) proposed rank-sum-type test statistics. Huang et al. (2005) extended these statistics to the general nonparametric Behrens-Fisher hypothesis problem and obtained improved test statistics by replacing the ad hoc variance with the asymptotic variance of the rank-sum statistics. In this paper we generalize the wo...
متن کاملProcedures for comparing samples with multiple endpoints.
Five procedures are considered for the comparison of two or more multivariate samples. These procedures include a newly proposed nonparametric rank-sum test and a generalized least squares test. Also considered are the following tests: ordinary least squares, Hotelling's T2, and a Bonferroni per-experiment error-rate approach. Applications are envisaged in which each variable represents a quali...
متن کاملA Robust Desirability-based Approach to Optimizing Multiple Correlated Responses
There are many real problems in which multiple responses should be optimized simultaneously by setting of process variables. One of the common approaches for optimization of multi-response problems is desirability function. In most real cases, there is a correlation structure between responses so ignoring the correlation may lead to mistake results. Hence, in this paper a robust approach based ...
متن کاملFace Recognition Based Rank Reduction SVD Approach
Standard face recognition algorithms that use standard feature extraction techniques always suffer from image performance degradation. Recently, singular value decomposition and low-rank matrix are applied in many applications,including pattern recognition and feature extraction. The main objective of this research is to design an efficient face recognition approach by combining many tech...
متن کاملA superiority - equivalence approach to one - sided tests on multiple endpoints in clinical trials
This paper considers the problem of comparing a new treatment with a control based on multiple endpoints. The hypotheses are formulated with the goal of showing that the treatment is equivalent, i.e. not inferior, on all endpoints and superior on at least one endpoint compared to the control, where thresholds for equivalence and superiority are specified for each endpoint. Roy’s (1953) union-in...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Statistics in Medicine
سال: 2016
ISSN: 0277-6715
DOI: 10.1002/sim.6928